Genetic causes of cancer predisposition in children and adolescents
Identifieur interne : 001D42 ( Main/Exploration ); précédent : 001D41; suivant : 001D43Genetic causes of cancer predisposition in children and adolescents
Auteurs : Federica Saletta ; Luciano Dalla Pozza ; Jennifer A. ByrneSource :
- Translational Pediatrics [ 2224-4344 ] ; 2015.
Abstract
The acquisition of
Url:
DOI: 10.3978/j.issn.2224-4336.2015.04.08
PubMed: 26835363
PubMed Central: 4729088
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic causes of cancer predisposition in children and adolescents</title><author><name sortKey="Saletta, Federica" sort="Saletta, Federica" uniqKey="Saletta F" first="Federica" last="Saletta">Federica Saletta</name></author><author><name sortKey="Dalla Pozza, Luciano" sort="Dalla Pozza, Luciano" uniqKey="Dalla Pozza L" first="Luciano" last="Dalla Pozza">Luciano Dalla Pozza</name></author><author><name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26835363</idno><idno type="pmc">4729088</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729088</idno><idno type="RBID">PMC:4729088</idno><idno type="doi">10.3978/j.issn.2224-4336.2015.04.08</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000871</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000871</idno><idno type="wicri:Area/Pmc/Curation">000871</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000871</idno><idno type="wicri:Area/Pmc/Checkpoint">001224</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001224</idno><idno type="wicri:Area/Ncbi/Merge">007E24</idno><idno type="wicri:Area/Ncbi/Curation">007E24</idno><idno type="wicri:Area/Ncbi/Checkpoint">007E24</idno><idno type="wicri:Area/Main/Merge">001D45</idno><idno type="wicri:Area/Main/Curation">001D42</idno><idno type="wicri:Area/Main/Exploration">001D42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic causes of cancer predisposition in children and adolescents</title><author><name sortKey="Saletta, Federica" sort="Saletta, Federica" uniqKey="Saletta F" first="Federica" last="Saletta">Federica Saletta</name></author><author><name sortKey="Dalla Pozza, Luciano" sort="Dalla Pozza, Luciano" uniqKey="Dalla Pozza L" first="Luciano" last="Dalla Pozza">Luciano Dalla Pozza</name></author><author><name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name></author></analytic><series><title level="j">Translational Pediatrics</title><idno type="eISSN">2224-4344</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The acquisition of <italic>de novo</italic> somatic mutations accounts for approximately 90% of all new cancer diagnoses, while the remaining 10% is due to inherited genetic traits. In this latter category, individuals harbouring germline mutations show a higher likelihood of developing potentially life-threatening cancers, often at a very young age. The study of cancer genetics has profoundly helped our understanding of cancer biology, leading to better characterised malignancies, tailored targeted therapies and the identification of individuals at high risk of cancer diagnosis. This review will discuss examples of cancer syndromes in children, adolescents and young adults, the main underlying gene mutations, and the use of genetic testing to identify gene mutation carriers. Finally, we will describe how gene mutation detection is employed for the life-long management of patients with high susceptibility to cancer, including genetic counselling, increased surveillance, early intervention and use of targeted therapies.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name><name sortKey="Dalla Pozza, Luciano" sort="Dalla Pozza, Luciano" uniqKey="Dalla Pozza L" first="Luciano" last="Dalla Pozza">Luciano Dalla Pozza</name><name sortKey="Saletta, Federica" sort="Saletta, Federica" uniqKey="Saletta F" first="Federica" last="Saletta">Federica Saletta</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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